Iacopo V Appiani (1480 – 20 October 1545) was the lord of Piombino of the Appiani (or Appiano) dynasty from 1511 until his death. He was born in

Piombino Piombino is an Italian town and ''comune'' of about 35,000 inhabitants in the province of Livorno (Tuscany). It lies on the border between the Ligurian Sea and the Tyrrhenian Sea, in front of Elba Island and at the northern side of Maremma. Ove ...

, the son of

Iacopo IV Appiani Iacopo IV Appiani (1459 – 10 April 1510) was an Italian condottiero and lord of Piombino of the Appiani dynasty in the Renaissance. He was born in Piombino, the son of Iacopo III Appiani, of whom he continued the traditional alliance with the ...

, 1st Prince of Piombino and Princess Victoria Todeschini-Piccolomini. Iacopo V's paternal grandfather was Jacopo III, the 3rd lord of Piombino and Battistini Kampofregozo and of the daughter of

Doge of Genoa The Doge of Genoa ( lij, Dûxe, ; la, Januensium dux et populi defensor, "Commander of the Genoese and Defender of the People") was the ruler of the Republic of Genoa, a city-state and soon afterwards a maritime republic, from 1339 until the s ...

Jano I. His maternal grandfather was Antonio, the 1st Duke of Amalfi from Todeschini-Piccolomini, and of Princess Mary d'Aragona, illegitimate daughter of the Ferdinand the Ist, the King of Naples. Like his predecessors, he initially allied with the Aragonese of Naples, in his case by marrying Marianna of Aragon in 1510, widow of Roberto II Sanseverino. After Marianna's death, he married Emilia Ridolfi, niece of

Pope Leo X Pope Leo X ( it, Leone X; born Giovanni di Lorenzo de' Medici, 11 December 14751 December 1521) was head of the Catholic Church and ruler of the Papal States from 9 March 1513 to his death in December 1521. Born into the prominent political an ...

; she died soon afterwards, and Jacopo remarried with her sister Clarice. After her death he married a third time to Elena Salviati, daughter of Jacopo Salviati and Lucrezia de' Medici. He is sometimes argued to be the subject of

Rosso Fiorentino Giovanni Battista di Jacopo (8 March 1495 in Gregorian style, or 1494 according to the calculation of times in Florence where the year began on 25 March – 14 November 1540), known as Rosso Fiorentino (meaning "Red Florentine" in Italian) ...

's '' Portrait of a Young Man'' (Berlin). He was succeeded by his son Iacopo VI. His other son

Alfonso Alphons (Latinized ''Alphonsus'', ''Adelphonsus'', or ''Adefonsus'') is a male given name recorded from the 8th century (Alfonso I of Asturias, r. 739–757) in the Christian successor states of the Visigothic kingdom in the Iberian peninsula. ...

was admiral in the Navy of the Grand Duchy of Tuscany.

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